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1

A New Look at the Probabilities in Bingo

David B. Agard and Michael W. Shackleford

Journal:

College Mathematics Journal

Year:

2002

Language:

english

File:

PDF, 340 KB

english, 2002

2

Intestinal Lymphatic Transport Enhances the Post-Prandial Oral Bioavailability of a Novel Cannabinoid Receptor Agonist Via Avoidance of First-Pass Metabolism

Natalie L. Trevaskis, David M. Shackleford, William N. Charman, Glenn A. Edwards, Anne Gardin, Silke Appel-Dingemanse, Olivier Kretz, Bruno Galli, Christopher J. H. Porter

Journal:

Pharmaceutical Research

Year:

2009

Language:

english

File:

PDF, 185 KB

english, 2009

3

3′,4′-Bis-difluoromethoxycinnamoylanthranilate (FT061): An orally-active antifibrotic agent that reduces albuminuria in a rat model of progressive diabetic nephropathy

Williams, Spencer J., Zammit, Steven C., Cox, Alison J., Shackleford, David M., Morizzi, Julia, Zhang, Yuan, Powell, Andrew K., Gilbert, Richard E., Krum, Henry, Kelly, Darren J.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 803 KB

english, 2013

4

Muscarinic M5 receptors modulate ethanol seeking in rats

Berizzi, Alice E., Perry, Christina J., Shackleford, David M., Lindsley, Craig W., Jones, Carrie K., Chen, Nicola A., Sexton, Patrick M., Christopoulos, Arthur, Langmead, Christopher J., Lawrence, And

Journal:

Neuropsychopharmacology

Year:

2018

Language:

english

File:

PDF, 1.31 MB

english, 2018

5

Fermentor temperature as a tool for control of high-density perfusion cultures of mammalian cells

Sandra Chuppa, Yeong-Shou Tsai, Sungjin Yoon, Steve Shackleford, Carl Rozales, Ramadas Bhat, Grace Tsay, Cary Matanguihan, Konstantin Konstantinov, David Naveh

Journal:

Biotechnology and Bioengineering

Year:

1997

Language:

english

File:

PDF, 787 KB

english, 1997

6

Does stereoselective lymphatic absorption contribute to the enantioselective pharmacokinetics of halofantrine In Vivo?

David M. Shackleford, Christopher J. H. Porter, William N. Charman

Journal:

Biopharmaceutics & Drug Disposition

Year:

2003

Language:

english

File:

PDF, 75 KB

english, 2003

7

Preclinical comparison of intravenous melphalan pharmacokinetics administered in formulations containing either (SBE)7 m-β-cyclodextrin or a co-solvent system

Maria Koltun, Julia Morizzi, Kasiram Katneni, Susan A. Charman, David M. Shackleford, Michelle P. McIntosh

Journal:

Biopharmaceutics & Drug Disposition

Year:

2010

Language:

english

File:

PDF, 105 KB

english, 2010

8

A small-scale synthesis and enantiomeric resolution of (RS)-[1-14C]-2-Phenylpropionic acid and biosynthesis of its diastereomeric acyl glucuronides

David M. Shackleford, Peter J. Hayball, Geoffrey D. Reynolds, David P.G. Hamon, Allan M. Evans, Robert W. Milne, Roger L. Nation

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

2001

File:

PDF, 1.84 MB

2001

9

Impact of chlorpromazine self-association on its apparent binding constants with cyclodextrins: Effect of SBE7-β-CD on the disposition of chlorpromazine in the rat

Michelle P. McIntosh, Nathania Leong, Kasiram Katneni, Julia Morizzi, David M. Shackleford, Richard J. Prankerd

Journal:

Journal of Pharmaceutical Sciences

Year:

2010

Language:

english

File:

PDF, 192 KB

english, 2010

10

Discovery of CYT997: a structurally novel orally active microtubule targeting agent

Christopher J. Burns, Michael F. Harte, Xianyong Bu, Emmanuelle Fantino, Max Joffe, Harrison Sikanyika, Stephen Su, C. Elisabet Tranberg, Neil Wilson, Susan A. Charman, David M. Shackleford, Andrew F.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.32 MB

english, 2009

11

Simultaneous determination of OZ277, a synthetic 1,2,4-trioxolane antimalarial, and its polar metabolites in rat plasma using hydrophilic interaction chromatography

Ravi K. Bhamidipati, Julia Morizzi, Francis C.K. Chiu, David M. Shackleford, Susan A. Charman

Journal:

Journal of Chromatography B

Year:

2009

Language:

english

File:

PDF, 403 KB

english, 2009

12

Self-Micellization of Gemfibrozil 1-O-β Acyl Glucuronide in Aqueous Solution

David M. Shackleford, Richard J. Prankerd, Martin J. Scanlon, William N. Charman

Journal:

Pharmaceutical Research

Year:

2003

Language:

english

File:

PDF, 97 KB

english, 2003

13

Stereoselective Hepatic Disposition of Model Diastereomeric Acyl Glucuronides

David M. Shackleford, Roger L. Nation, R.W. Milne, P.J. Hayball, Allan M. Evans

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2004

Language:

english

File:

PDF, 343 KB

english, 2004

14

Use of recombinant factor VIIa in patients with warfarin-associated intracranial hemorrhage

David L. Brody, Venkatesh Aiyagari, Angela M. Shackleford, Michael N. Diringer

Journal:

Neurocritical Care

Year:

2005

Language:

english

File:

PDF, 127 KB

english, 2005

15

The effects of the phytoestrogenic isoflavone genistein on the hepatic disposition of preformed and hepatically generated gemfibrozil 1-O-acyl glucuronide in the isolated perfused rat liver

Anthony N. Lucas, Léonie R. Brogan, Roger L. Nation, Robert W. Milne, Allan M. Evans, David M. Shackleford

Journal:

Journal of Pharmacy and Pharmacology

Year:

2003

Language:

english

File:

PDF, 247 KB

english, 2003

16

Antimalarial Activity of Pyrroloiminoquinones from the Australian Marine Sponge Zyzzya sp.

Davis, Rohan A., Buchanan, Malcolm S., Duffy, Sandra, Avery, Vicky M., Charman, Susan A., Charman, William N., White, Karen L., Shackleford, David M., Edstein, Michael D., Andrews, Katherine T., Camp,

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 569 KB

english, 2012

17

Probing a potential in vivo drug–excipient interaction: Temporal effects of a modified β-cyclodextrin on the intravenous pharmacokinetics of a model high-affinity drug ligand

Anne Mannila, Julia Morizzi, Thuy Tien Nguyen, Susan A. Charman, Michelle P. Mcintosh, David M. Shackleford

Journal:

Journal of Pharmaceutical Sciences

Year:

2012

Language:

english

File:

PDF, 313 KB

english, 2012

18

3,5-Diaryl-2-aminopyridines as a Novel Class of Orally Active Antimalarials Demonstrating Single Dose Cure in Mice and Clinical Candidate Potential

Younis, Yassir, Douelle, Frederic, Feng, Tzu-Shean, Cabrera, Diego González, Manach, Claire Le, Nchinda, Aloysius T., Duffy, Sandra, White, Karen L., Shackleford, David M., Morizzi, Julia

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 517 KB

english, 2012

19

Lead Optimization of Aryl and Aralkyl Amine-Based Triazolopyrimidine Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity in Mice

Gujjar, Ramesh, El Mazouni, Farah, White, Karen L., White, John, Creason, Sharon, Shackleford, David M., Deng, Xiaoyi, Charman, William N., Bathurst, Ian, Burrows, Jeremy

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.55 MB

english, 2011

20

Antimalarial Pyrido[1,2- a ]benzimidazoles

Ndakala, Albert J., Gessner, Richard K., Gitari, Patricia W., October, Natasha, White, Karen L., Hudson, Alan, Fakorede, Foluke, Shackleford, David M., Kaiser, Marcel, Yeates, Clive, Charman, Susan A.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1024 KB

english, 2011

21

Identification of a Metabolically Stable Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Antimalarial Activity in Mice

Gujjar, Ramesh, Marwaha, Alka, El Mazouni, Farah, White, John, White, Karen L., Creason, Sharon, Shackleford, David M., Baldwin, Jeffrey, Charman, William N., Buckner, Frederick S., Charman, Susan, Ra

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 219 KB

english, 2009

22

Synthesis of acylated glycoconjugates as templates to investigate in vitro biopharmaceutical properties

Carroux, Cindy J., Moeker, Janina, Motte, Josephine, Lopez, Marie, Bornaghi, Laurent F., Katneni, Kasiram, Ryan, Eileen, Morizzi, Julia, Shackleford, David M., Charman, Susan A., Poulsen, Sally-Ann

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 512 KB

english, 2013

23

Discovery of 7-Hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[ b ]furan (BNC105), a Tubulin Polymerization Inhibitor with Potent Antiproliferative and Tumor Vascular Disrupting Properties

Flynn, Bernard L., Gill, Gurmit S., Grobelny, Damian W., Chaplin, Jason H., Paul, Dharam, Leske, Annabell F., Lavranos, Tina C., Chalmers, David K., Charman, Susan A., Kostewicz, Edmund, Shackleford,

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.51 MB

english, 2011

24

Design, structure–activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi

Keenan, Martine, Alexander, Paul W., Diao, Hugo, Best, Wayne M., Khong, Andrea, Kerfoot, Maria, Thompson, R. C. Andrew, White, Karen L., Shackleford, David M., Ryan, Eileen, Gregg, Alison D., Charman,

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 444 KB

english, 2013

25

Discovery and Structure–Activity Relationships of Pyrrolone Antimalarials

Murugesan, Dinakaran, Mital, Alka, Kaiser, Marcel, Shackleford, David M., Morizzi, Julia, Katneni, Kasiram, Campbell, Michael, Hudson, Alan, Charman, Susan A., Yeates, Clive, Gilbert, Ian H.

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.45 MB

english, 2013

26

Chronic stress accelerates pancreatic cancer growth and invasion: A critical role for beta-adrenergic signaling in the pancreatic microenvironment

Kim-Fuchs, Corina, Le, Caroline P., Pimentel, Matthew A., Shackleford, David, Ferrari, Davide, Angst, Eliane, Hollande, Frédéric, Sloan, Erica K.

Journal:

Brain, Behavior, and Immunity

Year:

2014

Language:

english

File:

PDF, 879 KB

english, 2014

27

L'HOPITAL CANTONAL, GENEVA.

Heikinheimo, Markku, Lawshé, Avril, Shackleford, Gregory M., Wilson, David B., MacArthur, Craig A.

Journal:

Year:

1881

Language:

english

File:

PDF, 383 KB

english, 1881

28

ACTIVITY OF GONADOTROPHIC PREPARATIONS

Heikinheimo, Markku, Lawshé, Avril, Shackleford, Gregory M., Wilson, David B., MacArthur, Craig A.

Journal:

Year:

1939

Language:

english

File:

PDF, 187 KB

english, 1939

29

Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs and central nervous system

Heikinheimo, Markku, Lawshé, Avril, Shackleford, Gregory M., Wilson, David B., MacArthur, Craig A.

Journal:

Mechanisms of Development

Year:

1994

Language:

english

File:

PDF, 1.92 MB

english, 1994

30

NOTES FROM INDIA.

Heikinheimo, Markku, Lawshé, Avril, Shackleford, Gregory M., Wilson, David B., MacArthur, Craig A.

Journal:

Year:

1932

Language:

english

File:

PDF, 341 KB

english, 1932

31

Orally Bioavailable 6-Chloro-7-methoxy-4(1 H )-quinolones Efficacious against Multiple Stages of Plasmodium

Cross, R. Matthew, Flanigan, David L., Monastyrskyi, Andrii, LaCrue, Alexis N., Sáenz, Fabián E., Maignan, Jordany R., Mutka, Tina S., White, Karen L., Shackleford, David M., Bathurst, Ian, Fronczek,

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.92 MB

english, 2014

32

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium

Jiménez-Díaz, María Belén, Ebert, Daniel, Salinas, Yandira, Pradhan, Anupam, Lehane, Adele M., Myrand-Lapierre, Marie-Eve, O’Loughlin, Kathleen G., Shackleford, David M., Justino de Almeida, Mariana,

Journal:

Proceedings of the National Academy of Sciences

Year:

2014

Language:

english

File:

PDF, 1.75 MB

english, 2014

33

The Effect of Intravenous Sulfobutylether 7 -β-Cyclodextrin on the Pharmacokinetics of a Series of Adamantane-Containing Compounds

Leong, Nathania J, Prankerd, Richard J, Shackleford, David M, Mcintosh, Michelle P

Journal:

Journal of Pharmaceutical Sciences

Year:

2015

Language:

english

File:

PDF, 307 KB

english, 2015

34

Loading-Washout Studies of the Stereoselective Sinusoidal Uptake of (R)- and (S)-2-Phenylpropionyl Acyl Glucuronide

Shackleford, David, Evans, Allan, Milne, Robert, Nation, Roger

Journal:

Current Drug Metabolism

Year:

2006

Language:

english

File:

PDF, 184 KB

english, 2006

35

ELQ-300 prodrugs for enhanced delivery and single dose cure of malaria

Miley, Galen P., Pou, Sovitj, Winter, Rolf, Nilsen, Aaron, Li, Yuexin, Kelly, Jane X., Stickles, Allison M., Mather, Michael W., Forquer, Isaac P., Pershing, April M., White, Karen, Shackleford, David

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2015

Language:

english

File:

PDF, 732 KB

english, 2015

36

Enantiomers of Nifurtimox Do Not Exhibit Stereoselective Anti-Trypanosoma cruzi Activity, Toxicity, or Pharmacokinetic Properties

Moraes, Carolina B., White, Karen L., Braillard, Stéphanie, Perez, Catherine, Goo, Junghyun, Gaspar, Luis, Shackleford, David M., Cordeiro-da-Silva, Anabela, Thompson, R. C. Andrew, Freitas-Junior, Lu

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2015

Language:

english

File:

PDF, 240 KB

english, 2015

37

PEGylated Interferon Displays Differences in Plasma Clearance and Bioavailability Between Male and Female Mice and Between Female Immunocompetent C57Bl/6J and Athymic Nude Mice

Landersdorfer, Cornelia B., Caliph, Suzanne M., Shackleford, David M., Ascher, David B., Kaminskas, Lisa M.

Journal:

Journal of Pharmaceutical Sciences

Year:

2015

Language:

english

File:

PDF, 468 KB

english, 2015

38

Practical Lessons in Murine Thoracic Lymph Duct Cannulations: Observations in Female and Male Mice Across Four Different Strains That Impact on “Cannulatability”

Caliph, Suzanne M., Shackleford, David M., Ascher, David B., Kaminskas, Lisa M.

Journal:

Journal of Pharmaceutical Sciences

Year:

2015

Language:

english

File:

PDF, 1.02 MB

english, 2015

39

Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922)

Zheng, Zhaohua, Pinson, Jo-Anne, Mountford, Simon J., Orive, Stephanie, Schoenwaelder, Simone M., Shackleford, David, Powell, Andrew, Nelson, Erin M., Hamilton, Justin R., Jackson, Shaun P., Jennings,

Journal:

European Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.49 MB

english, 2016

40

Evaluation of the Impact of Sulfobutylether7-β-Cydodextrin on the Liquid Chromatography-Mass spectrometry Analysis of Biological Samples Arising from In Vivo Pharmacokinetic Studies

Leong, Nathania J., Prankerd, Richard J., Shackleford, David M., Mcintosh, Michelle P.

Journal:

Journal of Pharmaceutical Sciences

Year:

2015

Language:

english

File:

PDF, 126 KB

english, 2015

41

Quantifying Uncertainty in the Ratio of Two Measured Variables: A Recap and Example

Shackleford, David M., Jamsen, Kris M.

Journal:

Journal of Pharmaceutical Sciences

Year:

2016

Language:

english

File:

PDF, 144 KB

english, 2016

42

Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage

Francisco, Amanda Fortes, Jayawardhana, Shiromani, Lewis, Michael D., White, Karen L., Shackleford, David M., Chen, Gong, Saunders, Jessica, Osuna-Cabello, Maria, Read, Kevin D., Charman, Susan A., Ch

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 1.94 MB

english, 2016

43

Revisiting the SAR of the Antischistosomal Aryl Hydantoin (Ro 13-3978)

Wang, Chunkai, Zhao, Qingjie, Vargas, Mireille, Jones, Jeremy O, White, Karen L., Shackleford, David M., Chen, Gong, Saunders, Jessica, Ng, Alice C. F., Chiu, Francis C. K., Dong, Yuxiang, Charman, Su

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 612 KB

english, 2016

44

Progress in Antischistosomal N,N' -Diarylurea SAR

Wu, Jianbo, Wang, Chunkai, Leas, Derek, Vargas, Mireille, White, Karen L., Shackleford, David M., Chen, Gong, Sanford, Austin G., Hemsley, Ryan M., Davis, Paul H., Dong, Yuxiang, Charman, Susan A., Ke

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 427 KB

english, 2017

45

A New Look at the Probabilities in Bingo

Agard, David B., Shackleford, Michael W.

Journal:

College Mathematics Journal

Year:

2002

Language:

english

File:

PDF, 828 KB

english, 2002

46

Granzyme B Cleaves Decorin, Biglycan and Soluble Betaglycan, Releasing Active Transforming Growth Factor-β1

Boivin, Wendy A., Shackleford, Marlo, Vanden Hoek, Amanda, Zhao, Hongyan, Hackett, Tillie L., Knight, Darryl A., Granville, David J., Reitsma, Pieter H.

Journal:

Year:

2012

Language:

english

File:

PDF, 558 KB

english, 2012

47

In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models

Wittlin, Sergio, Schleiferböck, Sarah, Scheurer, Christian, Ihara, Masataka, Itoh, Isamu, Burrows, Jeremy N, Fantauzzi, Pascal, Lotharius, Julie, Charman, Susan A, Morizzi, Julia, Shackleford, David M

Journal:

Drug Design Development and Therapy

Year:

2013

File:

PDF, 416 KB

2013

48

Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity

Kokkonda, Sreekanth, El Mazouni, Farah, White, Karen L., White, John, Shackleford, David M., Lafuente-Monasterio, Maria Jose, Rowland, Paul, Manjalanagara, Krishne, Joseph, Jayan T., Garcia-Pérez, Ado

Journal:

Year:

2018

Language:

english

File:

PDF, 1.55 MB

english, 2018

49

In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models

Wittlin, Sergio, Schleiferböck, Sarah, Scheurer, Christian, Ihara, Masataka, Itoh, Isamu, Burrows, Jeremy N, Fantauzzi, Pascal, Lotharius, Julie, Charman, Susan A, Morizzi, Julia, Shackleford, David M

Journal:

Drug Design Development and Therapy

Year:

2013

Language:

english

File:

PDF, 416 KB

english, 2013

50

Using Human Plasma as an Assay Medium in Caco-2 Studies Improves Mass Balance for Lipophilic Compounds

Katneni, Kasiram, Pham, Thao, Saunders, Jessica, Chen, Gong, Patil, Rahul, White, Karen L., Abla, Nada, Chiu, Francis C. K., Shackleford, David M., Charman, Susan A.

Journal:

Pharmaceutical Research

Year:

2018

Language:

english

File:

PDF, 1.45 MB

english, 2018